Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites
Dawidowski M., Emmanouilidis L., Kalel V. C., Tripsianes K., Schorpp K., Hadian K., Kaiser M., Mäser P., Kolonko M., Tanghe S., Rodriguez A., Schliebs W., Erdmann R., Sattler M., Popowicz G. M.Science, 2017-03-30; 355(6332), 1416-1420
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Great proof-of-concept study
Well written and clearly stated experimental flow, key results and overall structure of the paper.
This study is highly relevant for further clinical applications in developing treatments for trypanosoma caused diseases.